Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8.5
USERS' SCORE
Good
Based on 12 Reviews
8
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Folate (800 mcg L-methylfolate) (as L-methylfolate as Metafolin®)
1,333 mcg DFE
333%
Top Medical Research Studies
We conducted a case-control study to look into how maternal folic acid supplementation affects the risk of congenital heart disease (CHD) in children and whether genetic factors, specifically MTRR gene polymorphisms, play a role in this relationship.
Our research involved 595 children diagnosed with CHD and 605 healthy children. By using a multivariate logistic regression model, we were able to assess the impact of maternal folate intake and the offspring's genetic profiles on the likelihood of developing CHD and its various subtypes.
The findings were quite striking. We observed that children whose mothers took folic acid during pregnancy showed a significantly reduced risk of CHD. Specifically, this included notable reductions in certain types of heart defects such as atrial septal defect and ventricular septal defect. Interestingly, specific polymorphisms in the MTRR gene were also linked to an increased risk of CHD.
Most importantly, we found that when mothers supplemented with folic acid, it appeared to mitigate some of the risks associated with genetic variants in their children. However, we recognize the need for additional studies with larger populations and different designs to confirm these important findings.
Our research involved 595 children diagnosed with CHD and 605 healthy children. By using a multivariate logistic regression model, we were able to assess the impact of maternal folate intake and the offspring's genetic profiles on the likelihood of developing CHD and its various subtypes.
The findings were quite striking. We observed that children whose mothers took folic acid during pregnancy showed a significantly reduced risk of CHD. Specifically, this included notable reductions in certain types of heart defects such as atrial septal defect and ventricular septal defect. Interestingly, specific polymorphisms in the MTRR gene were also linked to an increased risk of CHD.
Most importantly, we found that when mothers supplemented with folic acid, it appeared to mitigate some of the risks associated with genetic variants in their children. However, we recognize the need for additional studies with larger populations and different designs to confirm these important findings.
Read More
8
We conducted a case-control study examining how maternal serum folate levels during early to mid-pregnancy might influence the risk of congenital heart disease (CHD) in their children. This research involved participants recruited from one of China's leading cardiac care centers between 2015 and 2018, giving us access to a wealth of valuable data.
Through careful matching of CHD cases and non-CHD controls based on maternal age, we wanted to pinpoint whether variations in folate levels—alongside vitamin B12 and homocysteine levels—had any effect on heart disease in infants. Our findings highlighted a concerning trend: low levels of maternal folate were tied to an increased risk of CHD in offspring. Interestingly, we also discovered that unusually high folate levels were associated with elevated risks.
As we reflected on these results, it's clear that there might be a delicate balance when it comes to folate levels during pregnancy. While ensuring adequate folate is essential, the risk associated with excessive levels prompts further questions. Future studies will be crucial to unpacking these relationships and understanding the mechanisms at play.
Through careful matching of CHD cases and non-CHD controls based on maternal age, we wanted to pinpoint whether variations in folate levels—alongside vitamin B12 and homocysteine levels—had any effect on heart disease in infants. Our findings highlighted a concerning trend: low levels of maternal folate were tied to an increased risk of CHD in offspring. Interestingly, we also discovered that unusually high folate levels were associated with elevated risks.
As we reflected on these results, it's clear that there might be a delicate balance when it comes to folate levels during pregnancy. While ensuring adequate folate is essential, the risk associated with excessive levels prompts further questions. Future studies will be crucial to unpacking these relationships and understanding the mechanisms at play.
Read More
9.5
We explored the effects of folate, a form of vitamin B, on heart problems associated with TANGO2-deficiency disorder (TDD). This genetic condition can lead to dangerous heart rhythms that don’t respond well to standard treatments. To dive deeper into this issue, we established patient-derived heart cells, known as iPSC-CMs, to mimic the heart abnormalities seen in TDD.
In our observations, we found that high doses of folate almost completely eliminated arrhythmias in these heart cells. Interestingly, our clinical observations revealed that TDD patients taking multivitamins, particularly those high in B vitamins, experienced a significant reduction in cardiac crises. This suggests that folate may play a critical role in protecting against these life-threatening heart issues.
Our findings not only highlight the potential of folate as an effective treatment but also emphasize the importance of considering dietary supplements in managing cardiac risks in patients with TDD. Thus, we believe that boosting folate intake could offer a valuable strategy to enhance heart health in those affected by this disorder.
In our observations, we found that high doses of folate almost completely eliminated arrhythmias in these heart cells. Interestingly, our clinical observations revealed that TDD patients taking multivitamins, particularly those high in B vitamins, experienced a significant reduction in cardiac crises. This suggests that folate may play a critical role in protecting against these life-threatening heart issues.
Our findings not only highlight the potential of folate as an effective treatment but also emphasize the importance of considering dietary supplements in managing cardiac risks in patients with TDD. Thus, we believe that boosting folate intake could offer a valuable strategy to enhance heart health in those affected by this disorder.
Read More
Most Useful Reviews
9
Reduced homocysteine levels
10 people found this helpful
I began taking one tablet daily alongside Solgar B12 and a few other vitamins to lower my homocysteine levels. After 1.5 months of this regimen, my levels dropped substantially from 10.6 to 5.6. I feel fantastic knowing that with lower homocysteine, my vessel health improves and the risk of heart disease decreases. My parents experienced similar results, confirming these vitamins' effectiveness.
Read More
10
Effective folate absorption
7 people found this helpful
The body digests folate very well! Unlike synthetic folic acid, L-methylfolate is biologically active and helps lower homocysteine levels, which in turn reduces the risk of cardiovascular diseases. Many people are unable to effectively convert regular folate to L-methylfolate due to genetic variations. Using ready-made L-methylfolate ensures better absorption and a range of health benefits.
Read More
6
Supports heart health
14 people found this helpful
Folate is an excellent vitamin that supports heart health. Metafolin, its bioactive form, also promotes a healthy nervous system and aids in the production of healthy red blood cells.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8.5
- All Researches
9.5
We explored the effects of folate, a form of vitamin B, on heart problems associated with TANGO2-deficiency disorder (TDD). This genetic condition can lead to dangerous heart rhythms that don’t respond well to standard treatments. To dive deeper into this issue, we established patient-derived heart cells, known as iPSC-CMs, to mimic the heart abnormalities seen in TDD.
In our observations, we found that high doses of folate almost completely eliminated arrhythmias in these heart cells. Interestingly, our clinical observations revealed that TDD patients taking multivitamins, particularly those high in B vitamins, experienced a significant reduction in cardiac crises. This suggests that folate may play a critical role in protecting against these life-threatening heart issues.
Our findings not only highlight the potential of folate as an effective treatment but also emphasize the importance of considering dietary supplements in managing cardiac risks in patients with TDD. Thus, we believe that boosting folate intake could offer a valuable strategy to enhance heart health in those affected by this disorder.
In our observations, we found that high doses of folate almost completely eliminated arrhythmias in these heart cells. Interestingly, our clinical observations revealed that TDD patients taking multivitamins, particularly those high in B vitamins, experienced a significant reduction in cardiac crises. This suggests that folate may play a critical role in protecting against these life-threatening heart issues.
Our findings not only highlight the potential of folate as an effective treatment but also emphasize the importance of considering dietary supplements in managing cardiac risks in patients with TDD. Thus, we believe that boosting folate intake could offer a valuable strategy to enhance heart health in those affected by this disorder.
Read More
We conducted a case-control study to look into how maternal folic acid supplementation affects the risk of congenital heart disease (CHD) in children and whether genetic factors, specifically MTRR gene polymorphisms, play a role in this relationship.
Our research involved 595 children diagnosed with CHD and 605 healthy children. By using a multivariate logistic regression model, we were able to assess the impact of maternal folate intake and the offspring's genetic profiles on the likelihood of developing CHD and its various subtypes.
The findings were quite striking. We observed that children whose mothers took folic acid during pregnancy showed a significantly reduced risk of CHD. Specifically, this included notable reductions in certain types of heart defects such as atrial septal defect and ventricular septal defect. Interestingly, specific polymorphisms in the MTRR gene were also linked to an increased risk of CHD.
Most importantly, we found that when mothers supplemented with folic acid, it appeared to mitigate some of the risks associated with genetic variants in their children. However, we recognize the need for additional studies with larger populations and different designs to confirm these important findings.
Our research involved 595 children diagnosed with CHD and 605 healthy children. By using a multivariate logistic regression model, we were able to assess the impact of maternal folate intake and the offspring's genetic profiles on the likelihood of developing CHD and its various subtypes.
The findings were quite striking. We observed that children whose mothers took folic acid during pregnancy showed a significantly reduced risk of CHD. Specifically, this included notable reductions in certain types of heart defects such as atrial septal defect and ventricular septal defect. Interestingly, specific polymorphisms in the MTRR gene were also linked to an increased risk of CHD.
Most importantly, we found that when mothers supplemented with folic acid, it appeared to mitigate some of the risks associated with genetic variants in their children. However, we recognize the need for additional studies with larger populations and different designs to confirm these important findings.
Read More
8
Folate may reduce heart defect risks
In our exploration of the connection between heart health and maternal nutrition, we focused on the role of folate and multivitamin supplements during pregnancy. We investigated how these supplements might help combat the risks posed by total volatile organic compounds (TVOCs)—harmful indoor air pollutants—on developing babies.
We conducted a case-control study involving pregnant women at different stages of gestation, gathering data on their supplement intake, measuring important nutrients in their blood, and assessing their exposure to indoor air pollutants. Our analysis revealed a concerning link between high indoor TVOC levels and increased rates of congenital heart disease (CHD) in newborns.
Excitingly, we found that regular intake of multivitamins, including folate, could help alleviate these risks. This suggests that ensuring proper nutrient intake could be a simple yet effective strategy for expectant mothers living in environments with high indoor pollution levels. Overall, our findings underline the potential protective benefits of folate and a well-balanced diet in promoting heart health for the next generation.
We conducted a case-control study involving pregnant women at different stages of gestation, gathering data on their supplement intake, measuring important nutrients in their blood, and assessing their exposure to indoor air pollutants. Our analysis revealed a concerning link between high indoor TVOC levels and increased rates of congenital heart disease (CHD) in newborns.
Excitingly, we found that regular intake of multivitamins, including folate, could help alleviate these risks. This suggests that ensuring proper nutrient intake could be a simple yet effective strategy for expectant mothers living in environments with high indoor pollution levels. Overall, our findings underline the potential protective benefits of folate and a well-balanced diet in promoting heart health for the next generation.
Read More
8
We conducted a case-control study examining how maternal serum folate levels during early to mid-pregnancy might influence the risk of congenital heart disease (CHD) in their children. This research involved participants recruited from one of China's leading cardiac care centers between 2015 and 2018, giving us access to a wealth of valuable data.
Through careful matching of CHD cases and non-CHD controls based on maternal age, we wanted to pinpoint whether variations in folate levels—alongside vitamin B12 and homocysteine levels—had any effect on heart disease in infants. Our findings highlighted a concerning trend: low levels of maternal folate were tied to an increased risk of CHD in offspring. Interestingly, we also discovered that unusually high folate levels were associated with elevated risks.
As we reflected on these results, it's clear that there might be a delicate balance when it comes to folate levels during pregnancy. While ensuring adequate folate is essential, the risk associated with excessive levels prompts further questions. Future studies will be crucial to unpacking these relationships and understanding the mechanisms at play.
Through careful matching of CHD cases and non-CHD controls based on maternal age, we wanted to pinpoint whether variations in folate levels—alongside vitamin B12 and homocysteine levels—had any effect on heart disease in infants. Our findings highlighted a concerning trend: low levels of maternal folate were tied to an increased risk of CHD in offspring. Interestingly, we also discovered that unusually high folate levels were associated with elevated risks.
As we reflected on these results, it's clear that there might be a delicate balance when it comes to folate levels during pregnancy. While ensuring adequate folate is essential, the risk associated with excessive levels prompts further questions. Future studies will be crucial to unpacking these relationships and understanding the mechanisms at play.
Read More
8
We investigated how folate treatment, particularly in the presence of specific genetic variations, impacts patients with heart disease and hypertension. The study included 540 individuals diagnosed with coronary heart disease, categorized into three groups based on their treatment: those receiving folic acid, those without it, and a control group with standard treatment.
We discovered that patients who received folic acid along with enalapril showed a significantly lower recurrence rate of cardiovascular events compared to those who did not receive folic acid. Furthermore, the group treated with folic acid exhibited improved cholesterol levels, indicating better heart health outcomes.
Importantly, we noted that a significant portion of the patients possessed the MTHFR C677T gene mutation, potentially impacting their response to treatment. Overall, our findings suggest that folic acid supplementation plays a crucial role in enhancing the treatment effects for patients with coronary heart disease, particularly for those at higher risk due to their genetic background.
By combining gene screening and folic acid treatment, we can potentially improve clinical outcomes in a population that often struggles with managing heart-related issues effectively.
We discovered that patients who received folic acid along with enalapril showed a significantly lower recurrence rate of cardiovascular events compared to those who did not receive folic acid. Furthermore, the group treated with folic acid exhibited improved cholesterol levels, indicating better heart health outcomes.
Importantly, we noted that a significant portion of the patients possessed the MTHFR C677T gene mutation, potentially impacting their response to treatment. Overall, our findings suggest that folic acid supplementation plays a crucial role in enhancing the treatment effects for patients with coronary heart disease, particularly for those at higher risk due to their genetic background.
By combining gene screening and folic acid treatment, we can potentially improve clinical outcomes in a population that often struggles with managing heart-related issues effectively.
Read More
User Reviews
USERS' SCORE
Good
Based on 12 Reviews
8
- All Reviews
- Positive Reviews
- Negative Reviews
9
Reduced homocysteine levels
10 people found this helpful
I began taking one tablet daily alongside Solgar B12 and a few other vitamins to lower my homocysteine levels. After 1.5 months of this regimen, my levels dropped substantially from 10.6 to 5.6. I feel fantastic knowing that with lower homocysteine, my vessel health improves and the risk of heart disease decreases. My parents experienced similar results, confirming these vitamins' effectiveness.
Read More
10
Effective folate absorption
7 people found this helpful
The body digests folate very well! Unlike synthetic folic acid, L-methylfolate is biologically active and helps lower homocysteine levels, which in turn reduces the risk of cardiovascular diseases. Many people are unable to effectively convert regular folate to L-methylfolate due to genetic variations. Using ready-made L-methylfolate ensures better absorption and a range of health benefits.
Read More
6
Supports heart health
14 people found this helpful
Folate is an excellent vitamin that supports heart health. Metafolin, its bioactive form, also promotes a healthy nervous system and aids in the production of healthy red blood cells.
Read More
7.5
Essential for heart health
6 people found this helpful
Folate, or vitamin B9, is crucial for DNA and amino acid production, necessary for cell growth. It supports brain function, red blood cell formation, the immune system, and helps lower homocysteine, a factor linked to heart disease. The recommended daily intake varies by age and condition, and this supplement provides a necessary boost when levels drop. I highly recommend it!
Read More
9
Important for pregnancy
4 people found this helpful
This product is remarkable! Folic acid, an essential B-vitamin, is crucial for health, particularly for pregnant women or those planning to conceive. Many people are folate deficient, impacting cardiovascular health and increasing risks of neurological issues. I believe folate is vital for supporting both maternal health and addressing deficiencies.
Read More
Frequently Asked Questions
9
Reduced homocysteine levels
10 people found this helpful
I began taking one tablet daily alongside Solgar B12 and a few other vitamins to lower my homocysteine levels. After 1.5 months of this regimen, my levels dropped substantially from 10.6 to 5.6. I feel fantastic knowing that with lower homocysteine, my vessel health improves and the risk of heart disease decreases. My parents experienced similar results, confirming these vitamins' effectiveness.
10
Effective folate absorption
7 people found this helpful
The body digests folate very well! Unlike synthetic folic acid, L-methylfolate is biologically active and helps lower homocysteine levels, which in turn reduces the risk of cardiovascular diseases. Many people are unable to effectively convert regular folate to L-methylfolate due to genetic variations. Using ready-made L-methylfolate ensures better absorption and a range of health benefits.
7.5
Enhanced cardiovascular support
Solgar Folate offers a high-quality, easily absorbable form of folate essential for cellular health and heart support. I noticed increased energy and overall wellbeing after including it in my routine. It's an excellent choice for anyone looking to improve cardiovascular and nervous system health.
6
Supports heart health
14 people found this helpful
Folate is an excellent vitamin that supports heart health. Metafolin, its bioactive form, also promotes a healthy nervous system and aids in the production of healthy red blood cells.
6
Immediate absorption benefits
For optimal absorption, folic acid must be converted into an active form. Metafolin (L-methylfolate) is ready for the body to absorb and beneficial for those who struggle with conversion. It promotes heart health and supports the nervous system as well as healthy red blood cell formation.
0
Caused discomfort
They negatively affected my heart, causing a lack of air, shortness of breath, and a loud heartbeat. Caution is needed when using them as they were unsuitable for both me and my husband.
8
Folate may reduce heart defect risks
In our exploration of the connection between heart health and maternal nutrition, we focused on the role of folate and multivitamin supplements during pregnancy. We investigated how these supplements might help combat the risks posed by total volatile organic compounds (TVOCs)—harmful indoor air pollutants—on developing babies.
We conducted a case-control study involving pregnant women at different stages of gestation, gathering data on their supplement intake, measuring important nutrients in their blood, and assessing their exposure to indoor air pollutants. Our analysis revealed a concerning link between high indoor TVOC levels and increased rates of congenital heart disease (CHD) in newborns.
Excitingly, we found that regular intake of multivitamins, including folate, could help alleviate these risks. This suggests that ensuring proper nutrient intake could be a simple yet effective strategy for expectant mothers living in environments with high indoor pollution levels. Overall, our findings underline the potential protective benefits of folate and a well-balanced diet in promoting heart health for the next generation.
We conducted a case-control study involving pregnant women at different stages of gestation, gathering data on their supplement intake, measuring important nutrients in their blood, and assessing their exposure to indoor air pollutants. Our analysis revealed a concerning link between high indoor TVOC levels and increased rates of congenital heart disease (CHD) in newborns.
Excitingly, we found that regular intake of multivitamins, including folate, could help alleviate these risks. This suggests that ensuring proper nutrient intake could be a simple yet effective strategy for expectant mothers living in environments with high indoor pollution levels. Overall, our findings underline the potential protective benefits of folate and a well-balanced diet in promoting heart health for the next generation.
We conducted a case-control study to look into how maternal folic acid supplementation affects the risk of congenital heart disease (CHD) in children and whether genetic factors, specifically MTRR gene polymorphisms, play a role in this relationship.
Our research involved 595 children diagnosed with CHD and 605 healthy children. By using a multivariate logistic regression model, we were able to assess the impact of maternal folate intake and the offspring's genetic profiles on the likelihood of developing CHD and its various subtypes.
The findings were quite striking. We observed that children whose mothers took folic acid during pregnancy showed a significantly reduced risk of CHD. Specifically, this included notable reductions in certain types of heart defects such as atrial septal defect and ventricular septal defect. Interestingly, specific polymorphisms in the MTRR gene were also linked to an increased risk of CHD.
Most importantly, we found that when mothers supplemented with folic acid, it appeared to mitigate some of the risks associated with genetic variants in their children. However, we recognize the need for additional studies with larger populations and different designs to confirm these important findings.
Our research involved 595 children diagnosed with CHD and 605 healthy children. By using a multivariate logistic regression model, we were able to assess the impact of maternal folate intake and the offspring's genetic profiles on the likelihood of developing CHD and its various subtypes.
The findings were quite striking. We observed that children whose mothers took folic acid during pregnancy showed a significantly reduced risk of CHD. Specifically, this included notable reductions in certain types of heart defects such as atrial septal defect and ventricular septal defect. Interestingly, specific polymorphisms in the MTRR gene were also linked to an increased risk of CHD.
Most importantly, we found that when mothers supplemented with folic acid, it appeared to mitigate some of the risks associated with genetic variants in their children. However, we recognize the need for additional studies with larger populations and different designs to confirm these important findings.
8
We investigated how folate treatment, particularly in the presence of specific genetic variations, impacts patients with heart disease and hypertension. The study included 540 individuals diagnosed with coronary heart disease, categorized into three groups based on their treatment: those receiving folic acid, those without it, and a control group with standard treatment.
We discovered that patients who received folic acid along with enalapril showed a significantly lower recurrence rate of cardiovascular events compared to those who did not receive folic acid. Furthermore, the group treated with folic acid exhibited improved cholesterol levels, indicating better heart health outcomes.
Importantly, we noted that a significant portion of the patients possessed the MTHFR C677T gene mutation, potentially impacting their response to treatment. Overall, our findings suggest that folic acid supplementation plays a crucial role in enhancing the treatment effects for patients with coronary heart disease, particularly for those at higher risk due to their genetic background.
By combining gene screening and folic acid treatment, we can potentially improve clinical outcomes in a population that often struggles with managing heart-related issues effectively.
We discovered that patients who received folic acid along with enalapril showed a significantly lower recurrence rate of cardiovascular events compared to those who did not receive folic acid. Furthermore, the group treated with folic acid exhibited improved cholesterol levels, indicating better heart health outcomes.
Importantly, we noted that a significant portion of the patients possessed the MTHFR C677T gene mutation, potentially impacting their response to treatment. Overall, our findings suggest that folic acid supplementation plays a crucial role in enhancing the treatment effects for patients with coronary heart disease, particularly for those at higher risk due to their genetic background.
By combining gene screening and folic acid treatment, we can potentially improve clinical outcomes in a population that often struggles with managing heart-related issues effectively.
8
We conducted a case-control study examining how maternal serum folate levels during early to mid-pregnancy might influence the risk of congenital heart disease (CHD) in their children. This research involved participants recruited from one of China's leading cardiac care centers between 2015 and 2018, giving us access to a wealth of valuable data.
Through careful matching of CHD cases and non-CHD controls based on maternal age, we wanted to pinpoint whether variations in folate levels—alongside vitamin B12 and homocysteine levels—had any effect on heart disease in infants. Our findings highlighted a concerning trend: low levels of maternal folate were tied to an increased risk of CHD in offspring. Interestingly, we also discovered that unusually high folate levels were associated with elevated risks.
As we reflected on these results, it's clear that there might be a delicate balance when it comes to folate levels during pregnancy. While ensuring adequate folate is essential, the risk associated with excessive levels prompts further questions. Future studies will be crucial to unpacking these relationships and understanding the mechanisms at play.
Through careful matching of CHD cases and non-CHD controls based on maternal age, we wanted to pinpoint whether variations in folate levels—alongside vitamin B12 and homocysteine levels—had any effect on heart disease in infants. Our findings highlighted a concerning trend: low levels of maternal folate were tied to an increased risk of CHD in offspring. Interestingly, we also discovered that unusually high folate levels were associated with elevated risks.
As we reflected on these results, it's clear that there might be a delicate balance when it comes to folate levels during pregnancy. While ensuring adequate folate is essential, the risk associated with excessive levels prompts further questions. Future studies will be crucial to unpacking these relationships and understanding the mechanisms at play.
References
- Ruan X, Shang W, Lu J, Li Z, Yang J, et al. Maternal multivitamin supplementation mitigates the risk of fetal congenital heart disease associated with high indoor total volatile organic compounds exposure in east china: a case-control study. Environ Health. 2024;23:110. doi:10.1186/s12940-024-01150-7
- Li L, Ou J, Chen Y, Chen Q, Luo M, et al. Association of maternal folic acid supplementation and offspring MTRR gene polymorphism with congenital heart disease: a hospital-based case-control study in Han population. J Health Popul Nutr. 2024;43:220. doi:10.1186/s41043-024-00699-w
- Qu Y, Liu X, Lin S, Bloom MS, Wang X, et al. Maternal Serum Folate During Pregnancy and Congenital Heart Disease in Offspring. JAMA Netw Open. 2024;7:e2438747. doi:10.1001/jamanetworkopen.2024.38747
- Ma L, Zeng L, Wang X. MTHFR C677T gene polymorphism in patients with coronary heart disease and hypertension treated with enalapril and folic acid: implications for prognosis. Cell Mol Biol (Noisy-le-grand). 2024;70:142. doi:10.14715/cmb/2024.70.9.20
- Xu W, Cao Y, Stephens SB, Arredondo MJ, Chen Y, et al. Folate as a potential treatment for lethal ventricular arrhythmias in TANGO2-deficiency disorder. JCI Insight. 2024;9. doi:10.1172/jci.insight.171005
